Line up the ingredients
The ingredients need to pass though the transporters at the bottom of the central portion of the screen and then down through the side slots. If they are not lined up correctly in the middle section, they will end up perched on the ledge next to the transporter. Look for opportunities to shift them from side to side before the drop.
Stripes and combos
You won't be able to make matches in the side slots. You will need to use horizontal stripes and combos. The striped and wrapped candy combo works best if you can set one up.